Can resistance to either isoniazid or rifampicin predict multidrug resistance tuberculosis (MDR-TB)

Abstract Background Previous studies have shown significant differences and lack clarity on whether resistance to either isoniazid or rifampicin can predict multidrug tuberculosis (MDR-TB). Some consider be a surrogate for MDR-TB. We, therefore, conducted this study determine Results A total of 315 Mycobacteria isolates were tested against isoniazid, rifampicin, ethambutol streptomycin using the phenotypic proportion method Lowenstein–Jensen media. showed most (88.9%, 280/315) not resistant any anti-TB tested, 5.7% (18/315) both 2.5% (8/315) only 1.3% (4/315) all four first-line anti-tuberculosis. Prediction MDR TB basing results sensitivity 100.0%, specificity 96.3%, diagnostic accuracy 96.5%, positive negative predictive values 62.1% respectively. Isoniazid had 98.3%, 98.4%, 78.3% based 62.1%, 94.9%, value 96.2%. Conclusions Resistance sub-optimally predicts Despite having high specificity, was 78.3%, suggesting that if is in isolation could result false positives MDR-TB cases, resulting into patients being unnecessarily subjected more toxic expensive second-line drugs, which are less effective compared drugs.